Intraamniotic Endotoxin Increases Lung Antioxidant Enzyme Activity in Preterm Lambs
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چکیده
منابع مشابه
Intra-amniotic endotoxin: chorioamnionitis precedes lung maturation in preterm lambs.
The inflammatory and lung maturational effects of intra-amniotic exposure to endotoxin were assessed in fetal lambs. Five hours to 25 days after intra-amniotic injection of endotoxin, preterm lambs were delivered at 119-125 days gestation. Intra-amniotic endotoxin caused an inflammatory cell infiltration in amnion/chorion at 5 h, which persisted for 25 days. At 5-15 h after endotoxin, amnion/ch...
متن کاملMaternal glucocorticoids increase endotoxin-induced lung inflammation in preterm lambs.
Antenatal betamethasone (Beta) is widely used in women with asymptomatic chorioamnionitis at risk for preterm delivery, but its effects on fetal inflammation are unstudied. Groups of ewes at 109 +/- 1 days of gestation received the following treatments: intra-amniotic (IA) saline (control), 0.5 mg/kg intramuscular Beta, 10 mg IA endotoxin (Endo), and Beta + 2 h later Endo (Beta + Endo). Beta su...
متن کاملEndotoxin-induced lung maturation in preterm lambs is not mediated by cortisol.
Antenatal exposure to glucocorticoids, amnionitis, intraamniotic interleukin (IL)-1alpha, or endotoxin can improve postnatal lung function after preterm delivery. The relationship between early lung maturation and the dose and duration of a proinflammatory stimulus has not been evaluated. The effects of proinflammatory stimuli on fetal plasma cortisol also have not been evaluated. We hypothesiz...
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Chronic lung injury from prolonged mechanical ventilation after premature birth inhibits the normal postnatal decrease in pulmonary vascular resistance (PVR) and leads to structural abnormalities of the lung circulation in newborn sheep. Compared with normal lambs born at term, chronically ventilated preterm lambs have increased pulmonary arterial smooth muscle and elastin, fewer lung microvess...
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CHEST / 105 / 3 / MARCH, 1994 / Supplement 115S 43 Long SE, Menon AS, Kato H, et al. Constant oxygen insufflation (COl) in a ventilatory failure model. Am Rev Respir Dis 1988; 138:630-35 44 Benditt J, Poliock M. Roa J, et al. Transtracheal delivery of gas decreases the oxygen cost of breathing. Am Rev Respir Dis 1993; 147:1207-10 45 Nahum A, Burke WC, Ravenscraft SA, et al. Lung mechanics and g...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 2003
ISSN: 0031-3998,1530-0447
DOI: 10.1203/01.pdr.0000055769.19891.c4